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pentobarbital will decrease the level or outcome of fludrocortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital will minimize the extent or impact of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Diminished AUC of tramadol as well as the Lively metabolite